Phytomedicine. 2013 Jul 15;20(10):947-50. doi: 10.1016/j.phymed.2013.03.017. Epub 2013 Apr 30.

Carmona FAngelucci MASales DSChiaratti TMHonorato FBBianchi RVPereira AM.


Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Spiritist Society "Terra de Ismael," Jardinópolis, Brazil.





There is no universally accepted and effective prophylaxis of migraine headache episodes. We aimed to investigate the effects ofLippia alba (Mill.) N. E. Brown (chemotype geranial-carvenone) in the treatment of migraine patients.


Twenty-one women were enrolled in a prospective, phase 2, non-controlled cohort study to orally receive hydroethanolic extract of L.alba leaves. Symptom intensity and impact were assessed using MIDAS and HIT-6 instruments before and after 2 months of treatment.


We observed a significant decrease on HIT-6 total score, as well as MIDAS number of missed days, number of headache days, and pain intensity. More than 70% of patients experienced a minimum 50% reduction on pain frequency.


Treatment with L. alba leaves (geranial-carvenone) hydroethanolic extract is a cheap, safe, widely available, highly effective therapy to reduce both the intensity and the frequency of headache episodes of women with migraine. Identifier: NCT01259947.



Headache, Lippia alba spec., Medicinal plant, Migraine, Phytotherapy

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