Phytomedicine. 2013 Jul 15;20(10):947-50. doi: 10.1016/j.phymed.2013.03.017. Epub 2013 Apr 30.

Carmona FAngelucci MASales DSChiaratti TMHonorato FBBianchi RVPereira AM.

 

Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Spiritist Society "Terra de Ismael," Jardinópolis, Brazil. carmona@fmrp.usp.br

 

 

Abstract

BACKGROUND:

There is no universally accepted and effective prophylaxis of migraine headache episodes. We aimed to investigate the effects ofLippia alba (Mill.) N. E. Brown (chemotype geranial-carvenone) in the treatment of migraine patients.

METHODS:

Twenty-one women were enrolled in a prospective, phase 2, non-controlled cohort study to orally receive hydroethanolic extract of L.alba leaves. Symptom intensity and impact were assessed using MIDAS and HIT-6 instruments before and after 2 months of treatment.

RESULTS:

We observed a significant decrease on HIT-6 total score, as well as MIDAS number of missed days, number of headache days, and pain intensity. More than 70% of patients experienced a minimum 50% reduction on pain frequency.

CONCLUSIONS:

Treatment with L. alba leaves (geranial-carvenone) hydroethanolic extract is a cheap, safe, widely available, highly effective therapy to reduce both the intensity and the frequency of headache episodes of women with migraine. ClinicalTrials.gov Identifier: NCT01259947.

 

KEYWORDS:

Headache, Lippia alba spec., Medicinal plant, Migraine, Phytotherapy

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